What Is Dolasetron

Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Dolasetron oral (taken by mouth) is used to prevent nausea and vomiting that may be caused by medicine to treat cancer (chemotherapy).
Dolasetron may also be used for purposes not listed in this medication guide.
Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Dolasetron injection is used to prevent nausea and vomiting caused by surgery.
Dolasetron injection may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not take dolasetron if you are allergic to it.
To make sure you can safely take dolasetron, tell your doctor if you have any of these other conditions:
  • kidney disease;
  • a serious heart condition such as "sick sinus syndrome";
  • a heart rhythm disorder such as slow heartbeats, or atrial fibrillation (fast, irregular heart rhythm);
  • personal or family history of long QT syndrome;
  • congestive heart failure; or
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether dolasetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Dolasetron should not be given to a child younger than 2 years old.
You should not receive dolasetron if you are allergic to it.
Dolasetron can cause serious heart rhythm problems. You should not use this medicine if you have a history of Long QT syndrome. Tell your doctor if anyone in your family has ever had this condition.
To make sure dolasetron is safe for you, tell your doctor if you have:
  • kidney disease;
  • a serious heart condition such as "sick sinus syndrome";
  • a heart rhythm disorder such as slow heartbeats, or atrial fibrillation (fast, irregular heart rhythm);
  • congestive heart failure; or
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
FDA pregnancy category B. Dolasetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether dolasetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Dolasetron Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • a light-headed feeling, like you might pass out;
  • slow heart rate, weak pulse, slow breathing;
  • swelling in your hands or feet;
  • little or no urinating; or
  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Common side effects may include:
  • mild headache;
  • mild dizziness;
  • drowsiness; or
  • pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have:
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • a light-headed feeling, like you might pass out;
  • slow heart rate, weak pulse, slow breathing;
  • little or no urinating; or
  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Common side effects may include:
  • headache, dizziness;
  • fast or slow heart rate;
  • chills, shivering, anxiety;
  • upset stomach, diarrhea;
  • tired feeling; or
  • pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dolasetron Interactions

Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
There are many other medicines that can increase your risk of heart rhythm problems if you use them together with dolasetron.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with dolasetron, especially:
  • anagrelide;
  • droperidol;
  • methadone;
  • ondansetron;
  • an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
  • cancer medicine--arsenic trioxide, vandetanib;
  • an antidepressant--citalopram, escitalopram;
  • anti-malaria medication--chloroquine, halofantrine;
  • heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
  • medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine.
This list is not complete. Other drugs may interact with dolasetron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
There are many other medicines that can increase your risk of heart rhythm problems if you use them together with dolasetron.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with dolasetron, especially:
  • anagrelide;
  • droperidol;
  • methadone;
  • ondansetron;
  • an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
  • cancer medicine--arsenic trioxide, vandetanib;
  • an antidepressant--citalopram, escitalopram;
  • anti-malaria medication--chloroquine, halofantrine;
  • heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
  • medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine.
This list is not complete. Other drugs may interact with dolasetron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Dolasetron Dosage

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Dolasetron is usually taken 1 hour before chemotherapy. Follow your doctor's instructions.
Store at room temperature away from moisture, heat, and light.
For adults, dolasetron is injected into a vein through an IV. For children, the medicine may be mixed with apple juice and given orally (by mouth). You will receive this injection in a clinic or hospital setting before or during surgery.
In most cases, only one dose of dolasetron is given while you are still under anesthesia, or as soon as you have symptoms of nausea or vomiting.
Dolasetron injection is not for preventing nausea or vomiting that is caused by chemotherapy or factors other than surgery.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include depression, tremors, feeling light-headed, fainting, or seizure (convulsions).
Tell your doctor if you forget to take your dose within 1 hour before chemotherapy. Do not take extra medicine to make up the missed dose.
Since dolasetron injection is usually given as single dose by a healthcare professional, you will not be on a frequent dosing schedule.

Dolasetron Pictures

Anzemet 100 mg, pink, oval, film coated