Artemether and lumefantrine is a combination medicine used to treat non-severe malaria.
This medication is used only to treat malaria. Do not use artemether and lumefantrine to prevent malaria.
Artemether and lumefantrine may also be used for purposes not listed in this medication guide.
Tell your doctor about all other medicines you use.
Some medicines can interact with artemether and lumefantrine and should not be used at the same time, especially: dexamethasone, nefazodone, rifampin, St. John's wort; certain antibiotics or antifungal medicines--clarithromycin, erythromycin, itraconazole, ketoconazole, posaconazole, rifampin, telithromycin, voriconazole; hepatitis C medication--boceprevir, telaprevir; HIV/AIDS medication--atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir; or seizure medication--carbamazepine, fosphenytoin, phenobarbital, phenytoin.
You should not use this medication if you are allergic to artemether or lumefantrine.
Some medicines can interact with artemether and lumefantrine and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:
- dexamethasone, nefazodone, rifampin, St. John's wort; or
- certain antibiotics or antifungal medicines--clarithromycin, erythromycin, itraconazole, ketoconazole, posaconazole, rifampin, telithromycin, voriconazole; hepatitis C medication--boceprevir, telaprevir; HIV/AIDS medication--atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir; or seizure medication--carbamazepine, fosphenytoin, phenobarbital, phenytoin.
- a history of heart disease or a recent heart attack;
- heart rhythm disorder, or a personal or family history of Long QT syndrome;
- liver or kidney disease;
- low levels of potassium or magnesium in your blood.
FDA pregnancy category C. It is not known whether artemether and lumefantrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.
It is not known whether artemether and lumefantrine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Artemether and lumefantrine should not be given to a child who weighs less than 11 pounds.
Artemether-lumefantrine Side Effects
Call your doctor at once if you have a serious side effect such as:
- worsening malaria symptoms;
- severe vomiting or loss of appetite;
- headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; or
- the first sign of any skin rash, no matter how mild.
Common side effects may include:
- mild weakness or dizziness, mild headache;
- joint or muscle pain; or
- cough.
Artemether-lumefantrine Interactions
Grapefruit and grapefruit juice may interact with artemether and lumefantrine and lead to unwanted side effects. Avoid the use of grapefruit products while taking artemether and lumefantrine.
Many drugs can interact with artemether and lumefantrine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with artemether and lumefantrine, especially:
- antibiotics or medicine to treat tuberculosis;
- an antidepressant;
- antipsychotic medication;
- heart rhythm medication;
- HIV/AIDS medication; or
- seizure medication or medicine for nerve pain in your face.
Artemether-lumefantrine Dosage
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Take artemether and lumefantrine with food, milk, pudding, oatmeal, or broth. The tablet may be crushed and mixed with 1 or 2 teaspoons of water for easier swallowing. You may also mix a crushed tablet with infant formula when giving this medication to a child. Start eating normally as soon as possible to help your body better absorb the medication.
If you vomit within 1 to 2 hours after taking this medication, take another dose. If your vomiting continues or you cannot eat, call your doctor.
Artemether and lumefantrine is usually given as a total of 6 doses over a period of 3 days. Carefully follow your doctor's instructions about how many tablets to take per dose. Artemether and lumefantrine doses are based on weight and age. The usual doses are as follows, unless your doctor tells you otherwise.
For people over 16 years old who weigh at least 77 pounds:
- Take four (4) tablets as an initial dose.
- Take 4 more tablets 8 hours later.
- Take 4 tablets in the morning and 4 tablets in the evening for the next 2 days.
- Take three (3) tablets as an initial dose.
- Take 3 more tablets 8 hours later.
- Take 3 tablets in the morning and 3 tablets in the evening for the next 2 days.
- Take two (2) tablets as an initial dose.
- Take 2 more tablets 8 hours later.
- Take 2 tablets in the morning and 2 tablets in the evening for the next 2 days.
- Take one (1) tablet as an initial dose.
- Take a second tablet 8 hours later.
- Take 1 tablet in the morning and 1 tablet in the evening for the next 2 days.
Store at room temperature away from moisture and heat.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.