Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL.
Arsenic trioxide may also be used for other purposes not listed in this medication guide.
Arsenic trioxide can cause a serious and sometimes fatal complication by changing the way your immune system works. Call your doctor at once if you have any signs of this condition, including fever, swelling, weight gain, pain when you breathe, rapid heart rate, feeling short of breath, or feeling like you might pass out.
Arsenic trioxide can also have harmful effects on your heart rhythm. This effect is increased when you also use certain other drugs. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with arsenic trioxide.
Get emergency medical help if you have a headache with chest pain and severe dizziness, and fast or pounding heartbeats.
You should not use arsenic trioxide if you are allergic to it.
To make sure arsenic trioxide is safe for you, tell your doctor if you have:
- a history of heart disease;
- a heart rhythm disorder or history of Long QT syndrome;
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
- kidney disease; or
- liver disease.
Arsenic trioxide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Arsenic Trioxide Side Effects
Arsenic trioxide can cause a serious and sometimes fatal complication by changing the way your immune system works. Call your doctor at once if you have any signs of this condition, including:
- fever, weight gain, feeling weak or tired;
- swelling in your ankles or feet;
- cough, pain when you breathe, rapid heart rate, feeling short of breath; or
- feeling like you might pass out.
- pale skin, easy bruising or bleeding;
- cough, sore throat;
- low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
- high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss).
- stomach pain, nausea, vomiting;
- constipation, diarrhea;
- headache, dizziness, anxiety, numbness or tingly feeling;
- joint or muscle pain, tired feeling, trouble sleeping; or
- mild itching or rash.
Arsenic Trioxide Interactions
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
Arsenic trioxide can have harmful effects on your heart rhythm. This effect is increased when you also use certain other drugs. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with arsenic trioxide, especially:
- amphotericin B;
- methadone;
- tacrolimus;
- vandetanib;
- an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
- an antidepressant--amitriptyline, citalopram, clomipramine, desipramine;
- anti-malaria medication--chloroquine, halofantrine, mefloquine;
- a diuretic or "water pill";
- heart rhythm medicine--amiodarone, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol;
- medicine to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;
- medicine to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone; or
- migraine headache medicine--sumatriptan, zolmitriptan.
Arsenic Trioxide Dosage
Arsenic trioxide is injected into a vein through an IV. A healthcare provider will give you this injection.While using arsenic trioxide, you may need frequent blood tests at your doctor's office. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
You must remain under the care of a doctor while you are using arsenic trioxide. Do not miss any follow-up appointments.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Call your doctor for instructions if you miss an appointment for your arsenic trioxide injection.