What Is Diphenhydr Amine Ibuprofen?
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.
The combination of diphenhydramine and ibuprofen is used to treat occasional insomnia associated with minor aches and pains.
Diphenhydramine and ibuprofen is not for use in treating sleeplessness without pain, or sleep problems that occur often.
Diphenhydramine and ibuprofen may also be used for purposes not listed in this medication guide.
You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, if you are unable to urinate, or if you have ever had a severe allergic reaction caused by taking aspirin.
Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, heart disease, or overactive thyroid.
Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen, especially in older adults.
Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines.
Do not use this medication just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, if you are unable to urinate, or if you have ever had a severe allergic reaction caused by taking aspirin.
Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or a thyroid disorder.
Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.
Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen, especially in older adults.
Ask a doctor or pharmacist if it is safe for you to take diphenhydramine and ibuprofen if you have:
- a history of heart attack, stroke, or blood clot;
- heart disease, congestive heart failure, high blood pressure;
- a history of stomach ulcers or bleeding;
- a colostomy or ileostomy;
- liver or kidney disease;
- enlarged prostate or urination problems;
- asthma;
- cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;
- polyps in your nose;
- systemic lupus erythematosus (SLE);
- a bleeding or blood clotting disorder; or
- if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
Diphenhydramine and ibuprofen may pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Do not use this medicine without medical advice if you are breast-feeding a baby.
Do not give this medication to a child younger than 12 years old. Always ask a doctor before giving an antihistamine to a child. Death can occur from the misuse of antihistamines in very young children.
Diphenhydr Amine Ibuprofen Side Effects
- chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
- black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- fast or uneven heart rate, feeling short of breath;
- mood changes;
- tremor, seizure (convulsions);
- unusual bleeding, unusual weakness; or
- urinating less than usual or not at all.
- day-time drowsiness, dizziness, "hangover" feeling;
- problems with memory or concentration;
- dry mouth, nose, or throat;
- mild itching or rash;
- upset stomach, mild heartburn, diarrhea, constipation;
- blurred vision;
- feeling nervous or restless; or
- ringing in your ears.
Diphenhydr Amine Ibuprofen Interactions
This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking ibuprofen.
Ask a doctor or pharmacist before using any cold, cough, allergy, or other sleep medicine. Antihistamines and NSAIDs are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or ibuprofen (or similar NSAIDs such as aspirin, naproxen, ketoprofen, and others).
Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by diphenhydramine.
Ask a doctor or pharmacist if it is safe for you to take diphenhydramine and ibuprofen if you are also using any of the following drugs:
- atropine (Atreza, Sal-Tropine);
- benztropine (Cogentin);
- diphenhydramine (Benadryl) applied to the skin;
- lithium (Eskalith, Lithobid);
- methotrexate (Rheumatrex, Trexall);
- topiramate (Topamax);
- zonisamide (Zonegran);
- anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
- aspirin or other NSAIDs such as naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
- bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;
- a blood thinner such as warfarin (Coumadin, Jantoven);
- bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
- a diuretic (water pill);
- heart or blood pressure medicine such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
- irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);
- steroids (prednisone and others); or
- ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).
Diphenhydr Amine Ibuprofen Dosage
Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines.
Do not take for longer than 10 days in a row. Talk with your doctor if your symptoms do not improve after 10 days of treatment, or if you have any new symptoms.
Take with food or milk to lessen stomach upset.
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.
Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
