Is it true that a high fever can cause brain damage?

It's possible, but it's extremely unlikely.
It's not unusual for a sick child to run a temperature of 104 or even 105 degrees Fahrenheit. To cause brain damage, a child's temperature would need to reach 107.6 degrees F — hard to imagine, unless the child was trapped in a hot car, for instance, or was very overdressed while feverish.
So try not to panic when your child has a fever. In fact, while a fever is a sign that something's wrong, in many instances it will help your child fight a bacterial or viral infection, both by raising his temperature — most bacteria and viruses thrive at 98.6 degrees F — and by spurring the immune system to make more infection-fighting white blood cells and antibodies.

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