Atorvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins."
Atorvastatin and ezetimibe is a combination medicine that reduces blood levels of "bad" cholesterol, such as low-density lipoprotein (LDL), apolipoprotein-B (apo-B), triglycerides, or non-high-density lipoprotein (non-HDL).
Atorvastatin and ezetimibe is used together with a low-fat diet and other treatments to lower total cholesterol in adults with familial hypercholesterolemia (an inherited type of high cholesterol).
It is not known whether atorvastatin and ezetimibe reduces your risk of heart disease.
Atorvastatin and ezetimibe may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have active liver disease or abnormal liver function tests.
Do not use atorvastatin and ezetimibe if you are pregnant or if you could become pregnant. Use effective birth control.
Do not breast-feed while using this medicine.
You should not use this medicine if you are allergic to atorvastatin (Lipitor) or ezetimibe (Vytorin, Zetia), or if you have:
- active liver disease;
- abnormal liver function tests; or
- if you are pregnant or breast-feeding.
- a thyroid disorder;
- a history of liver or kidney disease;
- a history of liver problems caused by alcohol;
- gallbladder disease or a history of gallstones;
- low blood pressure;
- a history of blood clot or stroke, including "mini-stroke" (TIA);
- diabetes;
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
- untreated or uncontrolled seizures;
- if you drink large amounts of alcohol; or
- if you are older than 65.
It is not known whether atorvastatin and ezetimibe passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Atorvastatin-ezetimibe Side Effects
In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Stop using this medicine and call your doctor at once if you have:
- nausea, upper stomach pain, loss of appetite;
- itching, unusual tiredness; or
- dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
- mild muscle pain;
- stomach pain, diarrhea; or
- joint pain.
Atorvastatin-ezetimibe Interactions
Avoid eating foods that are high in fat or cholesterol. Atorvastatin and ezetimibe will not be as effective in lowering your cholesterol if you do not follow a cholesterol lowering diet plan.
If you also take cholestyramine, colesevelam, or colestipol: Space your doses apart in order to take atorvastatin and ezetimibe either 2 hours before or 4 hours after you take any of these other medications.
Many drugs can interact with this medicine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with atorvastatin and ezetimibe, especially:
- colchicine;
- cyclosporine;
- digoxin, digitalis;
- imatinib;
- isoniazid;
- nefazodone;
- niacin, vitamin B3;
- St. John's wort;
- an antibiotic--clarithromycin, erythromycin, rifampin, telithromycin;
- antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
- birth control pills;
- a blood thinner (warfarin, Coumadin);
- heart medication--nicardipine, quinidine;
- hepatitis C medications--boceprevir, telaprevir;
- HIV/AIDS medication--atazanavir, darunavir, delavirdine, efavirenz, fosamprenavir, indinavir, lopinavir, nelfinavir, nevirapine, ritonavir, saquinavir, tipranavir;
- other cholesterol medications, especially fenofibrate, fenofibric acid, gemfibrozil, or any other "statin" medicine.
- seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
- tuberculosis medication--rifabutin, rifampin, rifapentine.
Atorvastatin-ezetimibe Dosage
Do not crush, chew, or dissolve an atorvastatin and ezetimibe tablet. Swallow it whole.
While using this medicine, you may need frequent blood tests.
If you have major surgery or a severe injury or infection, make sure any doctor caring for you knows you are taking atorvastatin and ezetimibe.
Store at room temperature away from moisture and heat. Keep the medicine in the foil pouch or plastic case when not in use.
After opening a foil pouch, store it in a dry place protected from light. Discard any tablets not used within 30 days after opening the pouch.
Each time you take a tablet out of a blister card, place the card back into the plastic case.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
