Omeprazole decreases the amount of acid produced in the stomach.
The combination of amoxicillin, clarithromycin, and omeprazole is used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori).
Amoxicillin, clarithromycin, and omeprazole may also be used for other purposes not listed in this medication guide.
You should not take this medication if you are allergic to amoxicillin (Amoxil, Augmentin, Moxatag), clarithromycin (Biaxin), omeprazole (Prilosec), or if you have liver disease, or a history of allergic reaction to any antibiotic.
Before you take this medication, tell your doctor if you have kidney disease, myasthenia gravis, or if you are allergic to any drugs.
There are many other drugs that can interact with this medication. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
While you are taking amoxicillin, clarithromycin, and omeprazole, do not take any of the following medications: ergotamine (Ergomar, Cafergot, Ercaf, Migergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), or pimozide (Orap).
A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease.
You should not take this medication if you are allergic to amoxicillin (Amoxil, Augmentin, Moxatag), clarithromycin (Biaxin), omeprazole (Prilosec), or if you have liver disease, or a history of allergic reaction to any antibiotic.
Taking any of the following medicines together with amoxicillin, clarithromycin, and omeprazole can cause a life-threatening side effect on your heart:
- ergotamine (Ergomar, Cafergot, Ercaf, Migergot);
- dihydroergotamine (D.H.E. 45, Migranal Nasal Spray); or
- pimozide (Orap).
- kidney disease;
- myasthenia gravis; or
- if you are allergic to any drugs.
Omeprazole can pass into breast milk and may harm a nursing baby. Do not breast-feed while taking amoxicillin, clarithromycin, and omeprazole. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.
Amoxicillin/clarithromycin/omeprazole Side Effects
- hives;
- wheezing, difficulty breathing;
- blood in your urine, swelling, rapid weight gain, urinating more or less than usual;
- fever, swollen glands, rash or itching, joint pain, or general ill feeling;
- swelling of your face, lips, tongue, or throat; or
- severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
- diarrhea that is watery or bloody; or
- dizziness, fainting, fast or pounding heartbeat.
- headache, weakness;
- nausea, vomiting, stomach pain, heartburn, gas, indigestion;
- constipation, mild diarrhea;
- back pain;
- cold symptoms such as stuffy nose, sneezing, cough, sore throat; or
- unusual taste in your mouth.
Amoxicillin/clarithromycin/omeprazole Interactions
A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease.
Many drugs can interact with amoxicillin, clarithromycin, and omeprazole. Below is just a partial list. Tell your doctor if you are using:
- ampicillin (Omnipen, Principen);
- carbamazepine (Equetro, Carbatrol, Tegretol);
- cilostazol (Pletal);
- digoxin (Lanoxin, Lanoxicaps);
- ketoconazole (Nizoral);
- probenecid (Benemid);
- sildenafil (Viagra, Revatio);
- tacrolimus (Prograf);
- theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
- a blood thinner such as warfarin (Coumadin, Jantoven);
- cholesterol-lowering drugs such as lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync);
- a heart rhythm medication such as disopyramide (Norpace) or quinidine (Quin-G);
- HIV/AIDS medications such as atazanavir (Reyataz), nelfinavir (Viracept), or saquinavir (Invirase);
- iron supplements (Feosol, Mol-Iron, Fergon, Femiron, and others); or
- a sedative such as alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion).
Amoxicillin/clarithromycin/omeprazole Dosage
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.Each dose of this combination medication contains 4 pills (3 capsules and 1 tablet). Take all 4 pills twice daily before you eat, unless your doctor tells you otherwise.
Do not crush, chew, break, or open the pills. Swallow each pill whole. You may swallow the pills one at a time.
Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Amoxicillin and clarithromycin will not treat a viral infection such as the common cold or flu.
Amoxicillin can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are taking this medication.
Store at room temperature away from moisture, heat, and light.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
