What Is Amitiza (Lubiprostone)?
Amitiza belongs to a class of drugs known as chloride channel activators, which work by increasing the amount of fluid in your intestines, making it easier to pass stool.
It's prescribed to treat chronic idiopathic constipation (CIC) in adults. Idiopathic means the cause of the constipation is unknown and factors such as diet, underlying illness, or side effects from medications have been ruled out.
Amitiza may be prescribed to treat constipation caused by narcotic pain medications or opioids. In some cases, low doses of Amitiza are prescribed to treat irritable bowel syndrome with constipation (IBS-C) in women 18 and older.
Amitiza (lubiprostone) was approved by the Food and Drug Administration (FDA) in 2006. It's manufactured by Takeda.
Amitiza Warnings
The FDA warns a small number of patients develop dyspnea (difficulty breathing) when taking this drug. When this happens, patients describe a tightening in the chest and difficulty taking a breath within 30 to 60 minutes of taking their first dose.The problems usually go away in a few hours but can reoccur. While this reaction is not classified as a serious one, some people found the experience upsetting enough to discontinue taking the drug.
People with a history of certain stomach or intestinal problems, especially blockages in the stomach or bowels, severe diarrhea, or liver disease should make sure to tell their doctor before taking this medication.
Also, tell your healthcare provider if you've ever been diagnosed with gallstones, Crohn's disease, Hirschsprung's disease, impacted bowel movements, diverticulitis, polyps, or a hernia.
Always tell your healthcare professional about all prescription, non-prescription, over-the-counter, illegal and recreational drugs, herbal remedies, nutritional and dietary supplements, and any other drugs and treatments.
Pregnancy and Amitiza
If you are pregnant, planning a pregnancy or breastfeeding tell your doctor before taking Amitiza.Amitiza is in FDA Pregnancy Category C, meaning it there's some evidence it may harm a developing fetus and should only be taken when the benefits outweigh the risks. Your doctor can help you decide what's right for you if you are pregnant or planning a pregnancy.
It's not known if Amitiza passes into breast milk, but some studies indicate a nursing infant can develop side effects like diarrhea if the nursing mother is taking this drug. Talk to your physician about breastfeeding before taking Amitiza.
This drug has not been approved for children.
Amitiza (Lubiprostone) Side Effects
- Nausea
- Diarrhea (that is not severe)
- Heartburn
- Bloating
- Vomiting
- Dry mouth
- Runny nose
- Cough
- Gas
- Dizziness
- Headache
- Joint pain
- Back pain
- Trouble sleeping
Serious side effects of Amitiza:
- Severe diarrhea
- Swelling of arms and/or legs
- Changes in mental health
- Mood changes
- Rash
- Itching
- Swelling (especially in the face, tongue, or throat)
- Severe dizziness
- Trouble breathing
Amitiza may infrequently cause an episode of dyspnea (difficulty breathing). While this reaction is usually not serious and goes away within three hours, you may not be able to tell the difference between dyspnea and the severe reactions listed above.
Amitiza (Lubiprostone) Interactions
There is some evidence, however, that taking opioid type drugs, like methadone (Dolophine), may make Amitiza less effective.
Amitiza and Alcohol
This medication can make you dizzy. Drinking alcohol may increase this effect.Amitiza (Lubiprostone) Dosage
The usual dose to treat CIC or constipation caused by pain medication is 24 mcg. A lower dose, 8 mcg, is commonly prescribed to women over 18 who are diagnosed with IBS-C.
Amitiza may help relieve symptoms but should not be considered a cure for your condition. Keep taking this medication even if you feel well and do not stop without talking to your healthcare provider.
