What Is Amiloride?
Amiloride is used to treat or prevent hypokalemia (low potassium levels in the blood).
Amiloride may also be used for other purposes not listed in this medication guide.
Do not use this medication if you have kidney disease, urination problems, or high levels of potassium in your blood. Do not use potassium supplements or other diuretics while you are taking amiloride.
Before using this medication, tell your doctor if you have heart or liver disease, or a breathing disorder.
Avoid drinking alcohol, which can increase some of the side effects of amiloride.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Do not use this medication if you have:
- kidney disease or are unable to urinate;
- high potassium levels (hyperkalemia); or
- if you are taking potassium supplements, or another potassium-sparing diuretic such Moduretic, spironolactone (Aldactone, Aldactazide), or triamterene (Dyrenium, Dyazide, Maxzide).
- diabetes;
- heart disease;
- cirrhosis or other liver disease;
- a breathing disorder; or
- if you are using another diuretic.
It is not known whether amiloride passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Amiloride Side Effects
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- numbness or tingly feeling;
- muscle pain or weakness;
- slow, fast, or uneven heartbeat;
- feeling drowsy, restless, or light-headed;
- urinating less than usual or not at all;
- dry mouth, increased thirst, tiredness, nausea, vomiting;
- shallow breathing;
- tremors, confusion; or
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
- headache;
- mild nausea, loss of appetite;
- gas, stomach pain; or
- skin rash.
Amiloride Interactions
Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Before taking this medication, tell your doctor if you are using any of the following drugs:
- cyclosporine (Neoral, Sandimmune, Gengraf);
- tacrolimus (Prograf);
- lithium;
- an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
- indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.
Amiloride Dosage
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take each dose with a full glass of water.
Take amiloride with food.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.
Amiloride can interfere with the results of a glucose tolerance test. Stop using this medication for at least 3 days before you have this test. Tell any doctor who treats you that you are using amiloride.
Store this medication at room temperature away from heat, light, and moisture. Do not allow the tablets to freeze.
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include dizziness, thirst, feeling light-headed, slow heartbeat, or fainting.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.