What Is Argatroban?
Argatroban is used to treat or prevent blood clots in people who have thrombocytopenia (low levels of platelets in the blood) caused by using heparin. Argatroban is sometimes used in people who are undergoing a procedure called angioplasty (to open blocked arteries).
Argatroban may also be used for purposes not listed in this medication guide.
You should not use this medication if you are allergic to argatroban, or if you have any major bleeding from a surgery, injury, or other medical trauma.
Argatroban is not expected to be harmful to an unborn baby. However, aspirin is sometimes given with argatroban, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Before receiving argatroban, tell your doctor if you have liver disease, a stomach ulcer or bleeding, a bleeding or blood clotting disorder, untreated or uncontrolled high blood pressure, if you have recently had a spinal tap or epidural anesthesia, or if you have recently had major surgery (especially on your eyes, brain, or spinal cord).
Tell your doctor if you are using or receiving blood thinners or any other medications used to treat or prevent blood clots.
Because argatroban keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.
You should not receive this medication if you are allergic to argatroban, or if you have any major bleeding from a surgery, injury, or other medical trauma.
To make sure you can safely use argatroban, tell your doctor if you have any of these other conditions:
- a stomach ulcer or bleeding;
- liver disease;
- a bleeding or blood clotting disorder (such as hemophilia);
- untreated or uncontrolled high blood pressure (hypertension);
- if you have recently had a spinal tap or epidural anesthesia; or
- if you have recently had major surgery (especially eye surgery, brain surgery, or spinal cord surgery).
It is not known whether argatroban passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.
Argatroban Side Effects
Call your doctor at once if you have a serious side effect such as:
- feeling like you might pass out;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- blood in your urine;
- black, bloody, or tarry stools;
- coughing up blood or vomit that looks like coffee grounds;
- any bleeding that will not stop;
- pain or burning when you urinate;
- sudden numbness or weakness, problems with vision, speech, or balance;
- sudden severe headache, confusion, sudden changes in your senses of taste or touch;
- fever, chills, body aches, flu symptoms;
- cough with yellow or green mucus, stabbing chest pain, feeling short of breath;
- slow heart rate, weak pulse, slow breathing (breathing may stop); or
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
- nausea, vomiting, diarrhea, stomach pain;
- headache;
- back pain; or
- bleeding around the IV needle.
Argatroban Interactions
Avoid drinking alcohol. It may increase your risk of bleeding in your stomach or intestines.
Tell your doctor about all other medications you use or have recently received to prevent blood clots, such as:
- a blood thinner such as heparin or warfarin (Coumadin, Jantoven);
- abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat);
- dabigatran (Pradaxa), bivalirudin (Angiomax), lepirudin (Refludan);
- dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep); or
- alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase).
Argatroban Dosage
If you are receiving this injection during an angioplasty procedure, the medicine will be given throughout the entire procedure and for up to 24 hours after the procedure.
Argatroban is given around the clock until your blood coagulates properly. Your doctor will test your blood often to determine how long to treat you with argatroban.
To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Visit your doctor regularly.
Because argatroban keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.
Since argatroban is given by a healthcare professional, you are not likely to miss a dose.