Lansoprazole decreases the amount of acid produced in the stomach.
Amoxicillin, clarithromycin, and lansoprazole is a combination medicine used in people with Helicobacter pylori (H. pylori) infection and stomach ulcers. Treating H. pylori infection can help prevent future stomach ulcers.
Amoxicillin, clarithromycin, and lansoprazole may also be used for purposes not listed in this medication guide.
You should not take this medicine if you have a history of long QT syndrome or certain heart rhythm disorders, or a history of liver problems caused by taking clarithromycin.
You also should not take this medicine if you have ever had a severe allergic reaction to certain antibiotics, including azithromycin (Zithromax, Z-Pak), erythromycin, telithromycin, amoxicillin or other penicillins (ampicillin, Amoxil, Augmentin, Trimox, and others), or cephalosporins (Duricef, Keflex, Spectracef, and others).
Many drugs can interact with clarithromycin, and some can cause unwanted or dangerous effects when used at the same time. Tell your doctor about all medications you use, especially: cisapride, colchicine, pimozide, lovastatin, simvastatin, dihydroergotamine, ergotamine, ergonovine, or methylergonovine.
You should not take this medicine if you are allergic to amoxicillin (Amoxil), clarithromycin (Biaxin), or lansoprazole (Prevacid), or if:
- you have a history of long QT syndrome or certain heart rhythm disorders;
- you have ever had liver problems or jaundice caused by taking clarithromycin;
- you are allergic to azithromycin (Zithromax, Z-Pak), erythromycin, or telithromycin;
- you have had a severe allergic reaction to a penicillin antibiotic, including ampicillin, Augmentin, Principen, Timentin, Trimox, and others; or
- you have had a severe allergic reaction to a cephalosporin antibiotic such as cefdinir, cefprozil, cefuroxime, cephalexin, Duricef, Omnicef, Cefzil, Keflex, Spectracef, and others.
- cisapride;
- colchicine (if you also have liver or kidney disease);
- pimozide;
- lovastatin (Advicor, Altoprev, Mevacor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync); or
- ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine.
- liver disease;
- kidney disease;
- allergies;
- myasthenia gravis;
- osteoporosis; or
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
Amoxicillin can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking amoxicillin, clarithromycin, and lansoprazole.
Amoxicillin and lansoprazole can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Do not give this medicine to anyone under 18 years old without medical advice.
Amoxicillin/Clarithromycin/Lansoprazole Side Effects
Call your doctor at once if you have:
- diarrhea that is watery or bloody;
- fever, swollen glands, body aches, flu symptoms;
- skin rash, easy bruising or bleeding, severe tingling, numbness, pain, muscle weakness;
- upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
- irregular heart rhythm, feeling short of breath;
- headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
- confusion, nausea and vomiting, swelling, rapid weight gain, urinating less than usual or not at all;
- new or worsening cough with fever, trouble breathing; or
- severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
- diarrhea, constipation;
- headache;
- vaginal itching or discharge;
- nausea, vomiting, stomach pain;
- unusual or unpleasant taste in the mouth; or
- discolored teeth, black or "hairy" tongue.
Amoxicillin/Clarithromycin/Lansoprazole Interactions
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
A gout medicine called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and lansoprazole, especially if you are an older adult with kidney disease.
Many other drugs can interact with clarithromycin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with amoxicillin, clarithromycin, and lansoprazole, especially:
- atorvastatin (Lipitor, Caduet) or pravastatin (Pravachol);
- carbamazepine;
- insulin or oral diabetes medicine (especially nateglinide, pioglitazone, repaglinide, or rosiglitazone);
- warfarin (Coumadin, Jantoven);
- HIV or AIDS medicine--atazanavir, ritonavir, saquinavir;
- a Valium-type sedative--alprazolam, midazolam, triazolam;
- heart or blood pressure medication--amlodipine, diltiazem, verapamil;
- heart rhythm medication--amiodarone, disopyramide, dofetilide, dronedarone, ibutilide, procainamide, quinidine, sotalol; or
- sildenafil (Viagra) and other erectile dysfunction medicines--avanafil (Stendra), tadalafil (Cialis), vardenafil (Levitra).
Amoxicillin/Clarithromycin/Lansoprazole Dosage
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Each dose of this combination medicine contains 4 pills (3 capsules and 1 tablet). Take all 4 pills twice daily before you eat, unless your doctor tells you otherwise.
Do not crush, chew, break, or open the pills. Swallow each pill whole. You may swallow the pills one at a time.
Use amoxicillin, clarithromycin, and lansoprazole for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Amoxicillin, clarithromycin, and lansoprazole will not treat a viral infection such as the flu or a common cold.
This medicine can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using amoxicillin, clarithromycin, and lansoprazole.
Store at room temperature, away from moisture, heat, and light.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
